Portfolio

Alleviant

TMC AFFILIATIONS: BIODESIGN, TMCX5

Alleviant Medical is focused on developing a novel minimally-invasive device to treat congestive heart failure. Our proprietary technology is designed to relieve heart failure symptoms, improve quality of life, and reduce hospital admissions for over 16 million patients currently suffering from this disease in the US and EU.

Babyscripts

X04, DIGITAL HEALTH

Babyscripts’ market-leading pregnancy app is your digital front door to engage and remotely monitor pregnant & postpartum patients.

Briteseed

TMC AFFILIATION: TMCX3

Briteseed is commercializing a new class of smart surgical tools that have artificial-vision assistance to help surgeons quickly identify landmarks and safely navigate vital structures. These multifunctional tools have the benefit of cautery, dissection, and optical tissue sensing in a single package.

Clarium

Clarium is building the next-gen supply chain platform that healthcare needs now. We proactively manage supply disruptions, identify substitutes, forecast surgical demand, optimize inventory planning and eliminate match exceptions ever-present in our volatile era. Our AI-enabled workflow and data tools are dramatically enhancing productivity for healthcare staff at forward-thinking institutions. All so they can focus exclusively on providing exceptional patient care.

CNSDose

CNSDose uses advanced genetic technology to fast-track finding the right antidepressant and dose. Genetically guided prescribing via CNSDose results in a 2.5 times greater likelihood of remission, which means faster recovery, reducing suffering and cutting costs that result from trial-and-error prescribing.

CorInnova

TMC AFFILIATION: JLABS @ TMC

CorInnova is developing a soft robotic heart assist device that gently squeezes the heart in synchrony with the heartbeat to increase output. Delivered minimally invasively, the device is designed to bring a new paradigm of treatment to the 95 percent of heart failure patients who are ineligible for existing cardiac devices.

Crossbridge Bio

CrossBridge Bio is pioneering an approach to deliver the next generation of stable antibody-drug conjugates (ADC) therapeutics that carry dual payloads as targeted treatments for a range of challenging cancers. CrossBridge Bio’s headquarters are in Houston, TX, within the Texas Medical Center’s life sciences ecosystem.

Deep 6 AI | Tempus

TMC AFFILIATION: TMCX7

Deep 6 AI finds more, better matching patients for clinical trials in minutes rather than months by using artificial intelligence on clinical data.

Full details on the 2025 acquisition here.

Hamilton Health Box

Hamilton Health Box is the value-based primary care microclinic leader. HHB’s microclinic operating system leverages a hybrid primary care model to make healthcare accessible, convenient, and affordable for small footprint populations including small employers and rural populations. We aim to create healthier communities and reduce the total cost of healthcare through our high-touch primary care model.

Ictero Medical

TMC AFFILIATIONS: BIODESIGN, JLABS @ TMC

At Ictero Medical, we are developing the CholeSafe System, the first minimally invasive treatment option that helps decrease complications and costs while providing definitive therapy to high risk surgical patients with gallstone disease. Unlike laparoscopic cholecystectomy, the CholeSafe System can be used in the interventional radiology suite with only minimal local anesthesia to defunctionalize the gallbladder without having to remove it. This allows providers to give their patients the benefits of surgery, without the risk.

Intelligent Implants

Intelligent Implants is a bioelectronics company developing a revolutionary electrical stimulation platform technology that is incorporated into standard-of-care orthopedic implants. Its first product, SmartFuse, represents a novel method of delivering electric current to aid spinal fusion that can induce, direct, and monitor bone growth in real-time.

Koda Health

TMC AFFILIATION: TMC Biodesign Company

At Koda Health, we’re using AI to help guide difficult conversations in between providers and their elderly patients, starting with end-of-life healthcare.

Lena Health

Lena Health enables health systems and payers to scale care coordination and navigation support to patients who need it most, improving access to care and social resources within their own community. Lena Health does this through a telephonic AI care coordinator that can coordinate with patients, clinics, pharmacies, insurers, and community-based organizations.

Lifelet Medical

Lifelet Medical is developing a novel biomimetic leaflet material for heart valve replacements, transcending the durability and manufacturing limitations associated with current technology offerings.

Luma Health

TMC AFFILIATIONS: BIODESIGN, JLABS @ TMC

LumaHealth’s cloud-based platform empowers healthcare providers with HIPAA-compliant, mobile-first SMS and secure chat communication tools that enable frictionless patient-provider conversations — including intelligent scheduling, referral management, actionable reminders, and care pathway messaging.

March Biosciences

March Biosciences, Inc is a clinical-stage cell therapy company with a mission to transform patient care in the most challenging hematological malignancies. March Bio’s lead asset is at the end of Phase I trials for T-cell malignancies, diseases with a dismal prognosis that is currently unaddressed by CAR-T and targeted therapy technologies. The company’s pipeline is designed to expand on these early successes to more broadly impact other high-challenge cancers.

Medable

TMC AFFILIATION: TMCX4

Medable is transforming healthcare by providing an enterprise platform for “Direct-to-Patient” clinical care and clinical trials, enabling patient generated data to drive healthcare delivery, research, and personalized and predictive medicine.

Medical Informatics Corp.

TMC AFFILIATION: TMCX+ RESIDENT

MIC is a software company that provides real time patient monitoring and predictive analytics across the continuum of care in the hospital. Its innovative SickbayTM platform archives, aggregates, and transforms short-lived, high-resolution waveform data across disparate devices to enable anywhere, anytime remote monitoring. MIC applies machine learning to develop predictive algorithms, laying the groundwork for future AI-based solutions that predict patient risk and deterioration and enable data-driven medicine and patient-centered care.

Motif Neurotech

Motif Neurotech is powered by innovations in efficient wireless power and data, unlocking possibilities for new, miniature implants for tissue stimulation and diagnostic readings.

NarrativeDx | Press Ganey

TMC AFFILIATION: TMCX6

NarrativeDx uses AI to identify actionable insights from patient and provider feedback that improves patient satisfaction scores, increases operational efficiency and decreases employee turnover.

Full details on the 2020 acquisition  here.

Noninvasix

TMC AFFILIATION: TMCX1, JLABS @ TMC

Noninvasix will be the first company to non-invasively monitor the severity of sepsis and septic shock, enabling clinicians to diagnose and monitor the response to treatment of tissue hypoxia in real-time. Noninvasix’s patented optoacoustic platform technology is the first solution to non-invasively and continuously measure central venous saturation. Incorporating Noninvasix into the ICU workflow allows clinicians to more quickly and accurately diagnose their critically ill patients and tailor treatments to improve outcomes. Future developments, enhancements and evidence will expand the use and clinical impact of our technology into other indications and settings

Nua Surgical

Nua Surgical, a multi-award-winning Irish company, is redefining obstetric surgery with its patented SteriCISION C-Section Retractor.

Path EX, Inc.

TMC AFFILIATION: TMCX9

PATH EX, Inc. is focused on advancing a medical device that addresses an urgent unmet need. The company’s experienced team and institutional backing, combined with strong clinical evidence, represent an exciting breakthrough in the fight against sepsis.

Prana Thoracic

Building the future of early intervention in lung cancer.

Sonavex

TMC AFFILIATION: TMCX5

Sonavex’s two FDA approved products, EchoMark and EchoSure, enable ultrasound based vascular monitoring to detect flow compromises earlier.

Surf Therapeutics

Surf Therapeutics is developing the first non-invasive ultrasound therapeutic platform for the treatment of autoimmune disorders.

Trusted Health

TMC AFFILIATION: TMCX7

Trusted Health is an opportunity platform for the modern nurse, connecting top RNs to flexible nursing jobs at innovation employers.

Venostent

We’re a clinical-stage therapeutic medical device company that’s developed finely-tuned, bioabsorbable wraps intended to improve outcomes for the 5 million vascular surgeries performed each year.

Vivifi Medical

Vivifi Medical has developed the first suture-less laparoscopic technology that enables the connection of two vessels together for the treatment of Varicocele & Men’s Health Issues.

Volumetric | 3D Systems

TMC AFFILIATION: TMCX9

Volumetric Biotechnologies is focused on innovations in volumetric imaging and biotechnology, such as 3D imaging, bioprinting, tissue engineering, or other fields reliant on volumetric data.

Full details on the 2021 acquisition here.

Babyscripts

X04, DIGITAL HEALTH

Babyscripts’ market-leading pregnancy app is your digital front door to engage and remotely monitor pregnant & postpartum patients.

Briteseed

TMC AFFILIATION: TMCX3

Briteseed is commercializing a new class of smart surgical tools that have artificial-vision assistance to help surgeons quickly identify landmarks and safely navigate vital structures. These multifunctional tools have the benefit of cautery, dissection, and optical tissue sensing in a single package.

CNSDose

CNSDose uses advanced genetic technology to fast-track finding the right antidepressant and dose. Genetically guided prescribing via CNSDose results in a 2.5 times greater likelihood of remission, which means faster recovery, reducing suffering and cutting costs that result from trial-and-error prescribing.

CorInnova

TMC AFFILIATION: JLABS @ TMC

CorInnova is developing a soft robotic heart assist device that gently squeezes the heart in synchrony with the heartbeat to increase output. Delivered minimally invasively, the device is designed to bring a new paradigm of treatment to the 95 percent of heart failure patients who are ineligible for existing cardiac devices.

Deep 6 AI

TMC AFFILIATION: TMCX7

Deep 6 AI finds more, better matching patients for clinical trials in minutes rather than months by using artificial intelligence on clinical data.

Ictero Medical

TMC AFFILIATIONS: BIODESIGN, JLABS @ TMC

At Ictero Medical, we are developing the CholeSafe System, the first minimally invasive treatment option that helps decrease complications and costs while providing definitive therapy to high risk surgical patients with gallstone disease. Unlike laparoscopic cholecystectomy, the CholeSafe System can be used in the interventional radiology suite with only minimal local anesthesia to defunctionalize the gallbladder without having to remove it. This allows providers to give their patients the benefits of surgery, without the risk.

Intelligent Implants

Intelligent Implants is a bioelectronics company developing a revolutionary electrical stimulation platform technology that is incorporated into standard-of-care orthopedic implants. Its first product, SmartFuse, represents a novel method of delivering electric current to aid spinal fusion that can induce, direct, and monitor bone growth in real-time.

Luma Health

TMC AFFILIATIONS: BIODESIGN, JLABS @ TMC

LumaHealth’s cloud-based platform empowers healthcare providers with HIPAA-compliant, mobile-first SMS and secure chat communication tools that enable frictionless patient-provider conversations — including intelligent scheduling, referral management, actionable reminders, and care pathway messaging.

Medable

TMC AFFILIATION: TMCX4

Medable is transforming healthcare by providing an enterprise platform for “Direct-to-Patient” clinical care and clinical trials, enabling patient generated data to drive healthcare delivery, research, and personalized and predictive medicine.

Medical Informatics Corp.

TMC AFFILIATION: TMCX+ RESIDENT

MIC is a software company that provides real time patient monitoring and predictive analytics across the continuum of care in the hospital. Its innovative SickbayTM platform archives, aggregates, and transforms short-lived, high-resolution waveform data across disparate devices to enable anywhere, anytime remote monitoring. MIC applies machine learning to develop predictive algorithms, laying the groundwork for future AI-based solutions that predict patient risk and deterioration and enable data-driven medicine and patient-centered care.

NarrativeDx

TMC AFFILIATION: TMCX6

NarrativeDx uses AI to identify actionable insights from patient and provider feedback that improves patient satisfaction scores, increases operational efficiency and decreases employee turnover.

Full details on the 2020 acquisition here.

Noninvasix

TMC AFFILIATION: TMCX1, JLABS @ TMC

Noninvasix will be the first company to non-invasively monitor the severity of sepsis and septic shock, enabling clinicians to diagnose and monitor the response to treatment of tissue hypoxia in real-time. Noninvasix’s patented optoacoustic platform technology is the first solution to non-invasively and continuously measure central venous saturation. Incorporating Noninvasix into the ICU workflow allows clinicians to more quickly and accurately diagnose their critically ill patients and tailor treatments to improve outcomes. Future developments, enhancements and evidence will expand the use and clinical impact of our technology into other indications and settings

Sonavex

TMC AFFILIATION: TMCX5

Sonavex’s two FDA approved products, EchoMark and EchoSure, enable ultrasound based vascular monitoring to detect flow compromises earlier.

Trusted Health

TMC AFFILIATION: TMCX7

Trusted Health is an opportunity platform for the modern nurse, connecting top RNs to flexible nursing jobs at innovation employers.

Volmetric

TMC AFFILIATION: TMCX9, TMC @ JLABS TENANTS, RICE IP AND FOUNDERS

Volumetric, Inc. was founded in 2018 by Jordan Miller and Bagrat Grigoryan. Our mission is to empower the next generation of advanced biofabrication with high quality materials and systems for 3D bioprinting.

Full details on the 2021 acquisition here.